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ACE gene polymorphism in breast cancer patients of ethnic Kashmiri population
Nidda Syeed1, Safiya Abdullah2, A Syed Sameer3, Syed Akhtar Husain4, Saniya Nisar5, Afshana Rasool5, Mushtaq A Siddiqi4
1 Department of Immunology & Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir - 190 011; Department of Biosciences, Jamia Millia Islamia, New Delhi - 110 011, India
2 Department of Immunology & Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir - 190 011, India
3 Department of Immunology, Molecular Medicine and Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir - 190 011, India
4 Department of Biosciences, Jamia Millia Islamia, New Delhi - 110 011, India
5 Department of Clinical Biochemistry, University of Kashmir, Hazratbal - 190 006, India
Correspondence Address:
Mushtaq A Siddiqi
Department of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura
India
DOI: 10.4103/2229-5186.76986
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Background: The mitogenic and angiogenic effect of angiotensin II has been shown in breast cancer. Angiotensin II is converted from its inactive form to active form by the angiotensin I converting enzyme (ACE). Materials and Methods: To evaluate the effect of ACE gene in breast cancer patients and its effect on healthy control subjects, we studied 130 breast cancer patients and 220 healthy controls. Results: During our study, we found, the ACE genotype distribution in breast cancer patients were as follows: 62 (47.6%) had Deletion (DD), 43 (33.07%) had ID, and 25 (19.23%) had II (Insertion) genotypes, whereas in controls, 96 (43.63%) had DD, 107 (48.63%) had ID, and 25 (7.7%) had II genotypes. Conclusion: We conclude that our results implicate that ACE level/activity has been suggested to be protective against breast cancer, and therefore renin-angiotensin system may serve as a curative target for breast cancer detection, treatment, and prevention. Impact: Our study is the first report from India on Kashmiri population, suggesting that ACE activity can be a protective tool against breast cancer. |
