Year : 2012  |  Volume : 3  |  Issue : 2  |  Page : 95-105

A basic insight into the stability and manufacturing aspects of solid dispersions

1 Department of Pharmaceutics, School of Pharmacy, Suresh Gyan Vihar University, Jaipur, India
2 Department of Pharmaceutics, Grace College of Pharmacy, Calicut University, Kerala, India

Correspondence Address:
Ritu M Gilhotra
Head of Department, Department of Pharmaceutics, School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2229-5186.98668

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The development of a bioavailable dosage form is the most challenging task for the researchers. In the arena of advanced drug delivery systems, the solid dispersion techniques seem to be a promising system for the development of an optimized, bioavailable formulation of Class 2 drugs. The methods of formulation of solid dispersion have been summarized. This article is an effort to define a solid dispersion and its classification. The prospective of the stability of solid dispersion has also been discussed. Moreover, the major techniques that have been used so far such as the fusion/melting method, solvent evaporation method, hot melt extrusion method, supercritical fluid methods, have also been detailed.

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