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  Indian J Med Microbiol
 

Figure 1: Simplified diagram illustrating a central role of ROS in generating chronic inflammation and tissue damage in response to periodontal pathogens. MMP - Matrix metalloproteinase; TIMP - Tissue inhibitor of matrix metalloproteinase; NF-κB - Nuclear factor kappa B; AP-1 - Activating protein-1; PDL - Periodontal ligament; TNF - Tumor necrosis factor; IL - Interleukin; GM-CSF - Granulocyte– macrophage colony-stimulating factor; LPS - lipopolysaccharide; ROS - Reactive oxygen species

Figure 1: Simplified diagram illustrating a central role of ROS in generating chronic inflammation and tissue damage in response to periodontal pathogens. MMP - Matrix metalloproteinase; TIMP - Tissue inhibitor of matrix metalloproteinase; NF-κB - Nuclear factor kappa B; AP-1 - Activating protein-1; PDL - Periodontal ligament; TNF - Tumor necrosis factor; IL - Interleukin; GM-CSF - Granulocyte– macrophage colony-stimulating factor; LPS - lipopolysaccharide; ROS - Reactive oxygen species